Dried extract of Black Pepper (Piper nigrum L.), Long Pepper (Piper longum L.) and Ginger (Zingiber officinale Roscoe)
Based on 2.55 mg piperine and 1.38 mg gingerols in each capsule
The main compound found in black pepper and long pepper in PiperGin is a chemical substance called piperine that is thermogenic and it increases the bioavailability of nutrients and co-administered medications as well as enhancing metabolism. Gingerol and shogaol, the active constituents in ginger, suppress gastric contractions and gastric acid secretions and reduce nausea and vomiting.
Widespread use of black pepper, long pepper and ginger in food and drug culture of many nations has led to various pharmacological studies on them. Black pepper stimulates the taste buds in the mouth which increases digestive fluids reflexively(2). Piperine reveals anti-inflammatory effects due to the inhibition of prostaglandins synthesis(6). Ginger reduces blood sugar, regulates blood pressure, affects the cardiovascular system, inhibits prostaglandins and platelet aggregation, modifies lipid profile, stimulates bile excretion, reduces gastric acid secretion and even has anti-parasite effect(3). The pharmacological properties have been examined on the compounds of ginger including 6-, 10-gingerol, 6-, 10-dehydrogingerdione, 6-, 10-gingerdione, zingiberene and etc. For example, in aqueous and methanol extracts of ginger, the ability of reducing gastric acid secretions of 6-gingerol and zingiberene is comparable with cimetidine(4). The combination of black pepper, long pepper and ginger provides normal gastric support within upper digestive system along with stimulating peristaltic movements, saliva secretion and digestive fluids. PiperGin promotes normal digestive function including production of lipase, the enzyme responsible for breaking down dietary fat, and helps the digestive system respond normally to the occasional distention associated with large meals. It has a warming effect that "energizes" digestion and may also support the assimilation of other nutrients. PiperGin is a carminative substance and it supports the body's natural response to stomach discomfort(1).
Take two capsules orally during the day with a full glass of water after meal. It can be used by health care professional recommendation.
No side effects when properly used with therapeutic doses. Mucosal irritation and skin rash have been rarely reported in some sensitive individuals.
Excessive dosage of the drug is not advised during pregnancy and breastfeeding.
Dried extract of liquorice (Glycyrrhiza glabra L.)
Based on 73 mg glycyrrhizin in each capsule
Starches, pectins, polysaccharides, simple sugars, gums, mucilage, amino acids, triterpene saponin, flavonoids, mineral salts, bitters, essential oil, fat, asparagines, estrogen, tannins, glycosides, protein, resins, sterols, volatile oils and various other substances are components of liquorice root(1). The primary active ingredient, glycyrrhizin constitutes 10–25% of liquorice root extract. It is a saponin compound comprised of a triterpenoid aglycone, glycyrrhetic acid (glycyrrhetinic acid; enoxolone) conjugated to a disaccharide of glucuronic acid. Glycyrrhizin is considered as an anti-inflammatory and quenching agent of free radicals and also as blocking agent of lipid peroxidation chain reactions. Glycyrrhizin showed chemopreventive, antioxidant, and antiproliferative activity when tested on animal model. An analog of glycyrrhetic acid, carbenoxolone is useful in the treatment of alimentary tract ulcerative conditions like peptic ulcer. Flavonoids of liquorice include liquiritin, a chalcone (isoliquiritin) and other compounds. The isoflavones have considerable antioxidant and estrogen-like activity(2). Many volatile components are present in roots e.g. geraniol, pentanol, hexanol and an isolation of various compounds like propionic acid from the essential oil is also reported(3).
Liquorice extract have beneficial effects on preventing and treating of gastrointestinal diseases, especially gastric ulcers, flatulence and constipation and its flavonoids have anti-Helicobacter pylori activity(4). Licori Cap was found to be effective in the treatment of sore throat, cough and bronchial disease. Carbenoxolone stimulates gastric mucus secretion. Likewise, liquorice extract may also be able to stimulate tracheal mucus secretions producing demulcent and expectorant effects(5). High content of phenolic component in the extract of liquorice is responsible for its powerful antioxidant activity by means of significant free radical scavenging, hydrogen-donating, metal ion chelating and anti-lipid peroxidative. Antioxidant activity of liquorice flavonoids was found to be over 100 times stronger than that of antioxidant activity of vitamin E. Licori Cap also supports the normal function of the endocrine system and more specifically the adrenal glands efforts to produce normal levels of stress-combating hormones(6). Glycyrrhetinic acid in liquorice extract gives anti-inflammatory effect similar to glucocorticoids and mineralocorticoids. According to pharmacological studies, glycyrrhizic acid inhibits all factors responsible for inflammation. It inhibits cyclooxygenase activity and prostaglandin formation (specifically prostaglandin E2). It is also responsible for indirectly inhibiting platelet aggregation(7). The effect of liquorice extract on serum lipid profile and liver enzymes was studied in albino mice. Root extract of Glycyrrhiza glabra was found to have anti-lipidemic and anti-hyperglycemic activity at low doses(8). 18β-glycyrrhetic acid (an aglycone of glycyrrhizic acid) shows hepatoprotective activity by inhibiting both free radical generation and lipid peroxidation(9).
Take one capsule daily with water before a meal. It can be used by the recommendation of health care professional.
For patients with cardiovascular disorders, liver disorders and high blood pressure, the drug should be taken with caution.
The side effects are salt and water retention that increases the vascular blood pressure as well as reducing urine output which can lead to generalized edema.
Excessive dosage of the drug is not advised during pregnancy and breastfeeding.
Dried extracts of Milk Thistle (Silybum marianum L.), Dandelion (Taraxacum mongolicum L.), Schisandra (Schisandra chinensis Turcz.) and Psyllium Husk (Plantago ovata Forssk.)
Based on 120 mg Silymarin in each capsule
Silybum marianum contains silymarin, which is composed of the flavanolignans silybin, silydianin, and silychristine. The seeds also contain betaine, trimethylglycine and essential fatty acids, which may contribute to silymarin’s hepatoprotective and anti-inflammatory effects(1). Taraxacum spp. extract contains a large quantity of phenolic and flavonoid compounds, such as caffeic acid and luteolin. The phenolic and flavonoid compounds exhibit several pharmacological activities, such as antioxidative, anti-inflammatory and antiviral effects and they have been documented for the treatment of liver disorders(2). Schisandra chinensis extract has high total phenolic and flavonoid content, quercetin and hesperetin that have strong antioxidant activities and significant protective effect against acute hepatotoxicity(3).
Silymarin is effective in the treatment of both acute and chronic hepatitis. In acute viral hepatitis, administration of silymarin lead to shortening of treatment time and lowering serum bilirubin, AST and ALT. Using three capsules per day for six months, in patients with chronic hepatitis will improve the level of serum liver enzymes(4). Silymarin using result in a normalization of serum liver enzyme and total bilirubin levels in patients with alcoholic liver disease, in addition to improve liver tissue histology(5). In patients with cirrhosis, long-term (41 months) administration of silymarin result in a significant increase survival in compared to the placebo group(6). According to an animal study silymarin demonstrated an anticholesterolemic effect similar to probucol, with an increase in HDL cholesterol and a decrease in total and biliary cholesterol(7). The effect of Taraxacum mongolicum extract was observed in patients with chronic hepatitis B. The results showed that liver enzymes were significantly more likely to return to normal levels in patients who had been administered the preparation. Of the 51 patients receiving the treatment, eight were effectively cured, while in the control group, only one person was cured(8). Schisandra chinensis extract prevent the increase in serum ALT and AST level in acute liver damage, decrease the extent of malondialdehyde (MDA) formation and elevate the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver. The hepatoprotective effect of schisandra be related to its free radical scavenging effect, increasing antioxidant activity and inhibiting lipid peroxidation(3). Psyllium extract can cause hepatoprotective effect and can treat liver enzymes disorder and lipid profile in non-alcoholic fatty liver patients, either(9).
Take 1-3 capsules daily with meal or as directed by a healthcare professional.
No side effects when properly used with therapeutic doses.
It is not recommended during pregnancy and breastfeeding.
Kimia Faravar BuAli is a knowledge-based company that was established in 2015 with the aim of producing herbal medicines. Kimia Faravar BuAli produce herbal medicine such as PiperGin, Licori Cap and LiverFull 120 by supervision of food and drug administration of the Islamic Republic of Iran.
Pharmaceutical Technology Incubator, Buali (Avicenna) Institute, Buali Square, Ferdowsi Square, Mashhad, Iran.
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